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One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Gene Name: | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
Synonyms: | ST13, Aging-associated protein 2, AAG2, Hsc70-interacting protein, HSPABP1, HOP, Hsp70-interacting protein, HSPABP, FAM10A1, HIP, p48, PRO0786, Protein FAM10A1, Putative tumor suppressor ST13, SNC6, FAM10A4 |
Target Sequences: | NM_003932 NP_003923.2 P50502 |
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