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Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Gene Name: | steroid receptor RNA activator 1 |
Synonyms: | SRA1, SRAP, STRAA1, Pp7684, Steroid receptor coactivator, SRA |
Target Sequences: | NM_001035235 NP_001030312.2 Q9HD15 |
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