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Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Gene Name: | serine palmitoyltransferase, long chain base subunit 2 |
Synonyms: | SPTLC2, HSN1C, HLCB2a, KIAA0526, LCB2, LCB2A, SPT 2, NSAN1C, SPT2, LCB 2, Serine palmitoyltransferase 2 |
Target Sequences: | NM_004863 NP_004854.1 O15270 |
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