Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [B316]
IHC - Paraffin (5 - 10 µg/ml)
IHC - Frozen (5 - 10 µg/ml)
Immunofluorescence (10 - 20 µg/ml)
Western blot (1 - 5 µg/ml)
Specificity and Use
SPN / CD43 antibody was raised against the myeloblast cell line KG1.
This antibody reacts with a 95-115 kD protein on T-cells and thymocytes and a 115-135 kD molecules on neutrophils and platelets. These proteins are o-glycosylated and are mucin-like molecules with different antigenic epitopes.
50 mM sodium borate, 150 mM sodium chloride, 20% glycerol, 0.05% sodium azide, pH 8.0
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity).