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TATI / SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
Gene Name: | serine peptidase inhibitor, Kazal type 1 |
Synonyms: | SPINK1, PCTT, PSTI, TCP, TATI, Spink3 |
Target Sequences: | NM_003122 NP_003113.2 P00995 |
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