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Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Gene Name: | Spi-B transcription factor (Spi-1/PU.1 related) |
Synonyms: | SPIB, SPI-B, Spi-b transcription factor, Transcription factor Spi-B |
Target Sequences: | NM_003121 NP_003112.2 Q01892 |
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