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Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility.
Gene Name: | Spanx Family, Member D |
Synonyms: | SPANXD, Cancer/testis antigen 11.4, CT11.4, SPANX family, member D, SPANX family member D, SPAN-Xd protein, SPANX-C, SPANX-D, DJ171K16.1 |
Target Sequences: | NM_032417 Q9BXN6 |
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