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SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Gene Name: | suppressor of cytokine signaling 4 |
Synonyms: | SOCS4, CIS4, SOCS-4, SSI4, SOCS-7 |
Target Sequences: | NP_543143.1 Q8WXH5 |
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