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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SOCS1 Antibody (C‑Terminus) LS‑C10265
SOCS1 antibody LS-C10265 is an unconjugated rabbit polyclonal antibody to human SOCS1. Validated for WB.
Antibody
Catalog
Size
Price
LS-C10265-100
100 µg (0.25 mg/ml)
Unavailable

Popular SOCS1 Products

Antibody
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SOCS1 antibody LS-C31894 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Anti-SOCS1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2697 concentration 5 ug/ml.
Species: Human, Mouse, Rat
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Anti-SOCS1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2698 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Formalin-fixed and paraffin-embedded human colon carcinoma reacted with SOCS1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry

Product Description

SOCS1 antibody LS-C10265 is an unconjugated rabbit polyclonal antibody to human SOCS1. Validated for WB.
About SOCS1
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). O15524 NM_003745 NP_003736.1

SOCS1 Antibody, CIS1 Antibody, CISH1 Antibody, JAB Antibody, JAK-binding protein Antibody, JAK binding protein Antibody, STAT-induced STAT inhibitor 1 Antibody, SSI-1 Antibody, Tec-interacting protein 3 Antibody, TIP3 Antibody, SOCS-1 Antibody, SSI1 Antibody, STAT induced SH3 protein 1 Antibody, TIP-3 Antibody


Specifications

Target
Human SOCS1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 3 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
SOCS1 antibody was raised against a synthetic peptide derived from the C-terminal region of human, mouse or rat SOCS-1 protein.
Epitope
C-Terminus
Specificity
Reacts specifically with the ~30kD SOCS-1 protein. Reactivity was confirmed by Western blotting using mouse thymus cell lysates and HepG2 human hepatocellular carcinoma lysate. Based on amino sequence homology, this antibody is also expected to react with rat SOCS-1 protein.
Usage
Suitable for use in Western Blot. Western Blot: 1-3 ug/ml. Positive control: Mouse thymus cell lysates and HepG2 human hepatocellular carcinoma lysate.
Presentation
Antibody in PBS, pH 7.4, 0.1% sodium azide.
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/15/2018

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