Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
SOCS1 antibody was raised against a synthetic peptide derived from the C-terminal region of human, mouse or rat SOCS-1 protein.
Reacts specifically with the ~30kD SOCS-1 protein. Reactivity was confirmed by Western blotting using mouse thymus cell lysates and HepG2 human hepatocellular carcinoma lysate. Based on amino sequence homology, this antibody is also expected to react with rat SOCS-1 protein.
Suitable for use in Western Blot. Western Blot: 1-3 ug/ml. Positive control: Mouse thymus cell lysates and HepG2 human hepatocellular carcinoma lysate.
PBS, pH 7.4, 0.1% Sodium Azide
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).