Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
SNW1 / SKIP antibody was raised against the epitope recognized maps to a region between residue 500 and the C-terminus (residue 536) of human Nuclear Receptor Coactivator, 62 kD (SKIIP, SKI Interacting Protein) using the numbering given in entry NP_036377.1 (GeneID 22938).
Species cross-reactivity: Human and mouse. Other species have not been tested.
Suitable for use in Western Blot and Immunoprecipitation.
SNW1 Antibody, Bx42 Antibody, Homolog of Drosophila BX42 Antibody, Prp45 Antibody, PRPF45 Antibody, SKI interacting protein Antibody, SKIIP Antibody, SKIP Antibody, NCOA-62 Antibody, Nuclear protein SkiP Antibody, Ski-interacting protein Antibody, SNW domain containing 1 Antibody
Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation.