Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Goat Polyclonal (IgG) to Human SNCAIP / Synphilin 1
Human, Monkey, Dog
IHC - Paraffin, Western blot, ELISA
Human SNCAIP / Synphilin 1
Human, Monkey, Dog (tested or 100% immunogen sequence identity)
IHC - Paraffin (1:400), Western blot (1:2000), ELISA (1:5000)
Specificity and Use
SNCAIP / Synphilin 1 antibody was raised against peptide 829SLELNGEKDKDKGRTLQRT847. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog (100%); Bat, Horse (89%); Mouse, Bovine (84%).
Recognizes synphilin-1, a cytoplasmic protein which associates with alpha-synuclein in vivo. Alpha-Synuclein is a major component of Lewy bodies in patients with sporadic Parkinson's disease (PD) and mutations of alpha-synuclein are involved in familial forms of PD. Reports suggest that synphilin-1 may play a role in Lewy body formation in association with alpha synuclein.
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.