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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SNCAIP / Synphilin 1 Antibody (aa829‑847) LS‑C11522
Note: This antibody replaces LS-C86249, LS-C26318, LS-C122462
Synphilin 1 antibody LS-C11522 is an unconjugated goat polyclonal antibody to Synphilin 1 (SNCAIP) from human, dog and monkey. Validated for ELISA, IHC and WB.
Antibody
Catalog
Size
Price
LS-C11522-100
100 µl
$395

Popular SNCAIP / Synphilin 1 Products

Immunohistochemical analysis of Synphilin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, ELISA
Antibody
Species: Human
Applications: IHC, Western blot, ELISA
Western blot of Synphilin-1 antibody
Species: Human, Mouse
Applications: IHC, Western blot, ELISA

Product Description

Synphilin 1 antibody LS-C11522 is an unconjugated goat polyclonal antibody to Synphilin 1 (SNCAIP) from human, dog and monkey. Validated for ELISA, IHC and WB.

Specifications

Target
Human SNCAIP / Synphilin 1
Synonyms
SNCAIP, Synphilin-1, SYPH1, SPH1, Synphilin 1
Host
Goat
Reactivity
Human, Monkey, Dog (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:400)
  • Western blot (1:2000)
  • ELISA (1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Peptide 829SLELNGEKDKDKGRTLQRT847. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog (100%); Bat, Horse (89%); Mouse, Bovine (84%).
Epitope
aa829-847
Specificity
Recognizes synphilin-1, a cytoplasmic protein which associates with alpha-synuclein in vivo. Alpha-Synuclein is a major component of Lewy bodies in patients with sporadic Parkinson's disease (PD) and mutations of alpha-synuclein are involved in familial forms of PD. Reports suggest that synphilin-1 may play a role in Lewy body formation in association with alpha synuclein.
Presentation
Serum, 0.09% Sodium Azide
Restrictions
For research use only.
About SNCAIP / Synphilin 1
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Q9Y6H5 NM_005460 NP_005451.2


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Requested From: United States
Date Requested: 10/21/2018

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