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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMURF1 Antibody (Internal) LS‑C10239
Antibody
SMURF1 antibody LS-C10239 is an unconjugated rabbit polyclonal antibody to SMURF1 from human and mouse. Validated for WB.
Catalog
Size
Price
LS-C10239-100
100 µg
Unavailable

Popular SMURF1 Products

Antibody
Species: Human
Applications: Peptide Enzyme-Linked Immunosorbent Assay
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Anti-SMURF1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3450 concentration 10 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot
Anti-SMURF1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5471 concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Antibody
Species: Human, Mouse
Applications: Western blot, ELISA

Product Description

SMURF1 antibody LS-C10239 is an unconjugated rabbit polyclonal antibody to SMURF1 from human and mouse. Validated for WB.
About SMURF1
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Q9HCE7 NP_851994.1

SMURF1 Antibody, E3 ubiquitin ligase SMURF1 Antibody, KIAA1625 Antibody, HSMURF1 Antibody


Specifications

Target
Human SMURF1
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 3 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
SMURF1 antibody was raised against synthetic peptide derived from an internal region of human Smurf1 (Smad ubiquitination regulatory factor 1, Smad-specific E3 ubiquitin ligase 1, Smad-ubiquitin E3 ligase Smurf1-beta).
Epitope
Internal
Specificity
Reacts with human and mouse Smurf1. On Western blots, it identifies the target band at ~100kD. Reactivity has been confirmed with human A375, NGP96, HepG2, MeWo cell lysates, and mouse liver and testis homogenates. Based on amino acid sequence homology, reactivity with rat may also be observed.
Usage
Suitable for use in Western Blot. Western Blot: 1-3 ug/ml.
Presentation
PBS, pH 7.4, 0.1% sodium azide.
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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