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E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.
Gene Name: | SMAD specific E3 ubiquitin protein ligase 1 |
Synonyms: | SMURF1, E3 ubiquitin ligase SMURF1, KIAA1625, HSMURF1 |
Target Sequences: | NP_851994.1 Q9HCE7 |
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