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SMMHC / MYH11
Myosin, Heavy Chain 11, Smooth Muscle
SMMHC / MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Gene Name: | Myosin, Heavy Chain 11, Smooth Muscle |
| Synonyms: | MYH11, AAT4, FAA4, KIAA0866, Myosin-11, Myosin heavy chain 11, SMHC, SMMHC |
| Target Sequences: | NM_002474 NP_002465.1 P35749 |
Publications (2)
1
Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Jiang Y, Luo Y, Tang Y, Moats R, Warburton D, Zhou S, Lou J, Pryhuber GS, Shi W, Wang LL. Scientific reports. 2019 March;9:5296. [Full Text Article]
[PubMed:30923323]
[PMC:PMC6439218]
2
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Gervaise H Henry, Alicia Malewska, Diya B Joseph, Venkat S Malladi, Jeon Lee, Jose Torrealba, Ryan J Mauck, Jeffrey C Gahan, Ganesh V Raj, Claus G Roehrborn, Gary C Hon, Malcolm P MacConmara, Jeffrey C Reese, Ryan C Hutchinson, Chad M Vezina, Douglas W Strand. Cell reports. 2018 Dec;25:3530-3542e5. [Full Text Article]
[PubMed:30566875]
[PMC:PMC6411034]
Related Antibodies: LS-C390741.
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SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
SMMHC / MYH11 Mouse anti-Human Monoclonal (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Rabbit anti-Rat Polyclonal (aa211-482) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
SMMHC / MYH11 Rabbit anti-Human Recombinant Monoclonal (MYH11/2303R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
SMMHC / MYH11 Mouse anti-Human Monoclonal (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (SPM201) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM201) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Pig, Human
IHC-P, WB
Unconjugated
50 µl/$460
SMMHC / MYH11 Mouse anti-Human Monoclonal (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
SMMHC / MYH11 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
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