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Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Gene Name: | decapping mRNA 1A |
Synonyms: | DCP1A, Decapping enzyme hDcp1a, Nbla00360, HSA275986, Transcription factor SMIF, MRNA-decapping enzyme 1A, SMIF, SMAD4IP1 |
Target Sequences: | NM_018403 |
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