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Anti-SMC1A / SMC1 Antibody (phospho-Ser966) LS-C56969

Catalog Size Price
LS-C56969-100 100 µg Unavailable

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100% Guaranteed
Rabbit Polyclonal to Human SMC1A / SMC1
Western blot, Immunoprecipitation


Human SMC1A / SMC1
Human (tested or 100% immunogen sequence identity)
Affinity purified


  • Western blot (1:500 - 1:5000)
  • Immunoprecipitation

Specificity and Use

SMC1A / SMC1 antibody was raised against synthetic phosphopeptide corresponding to an amino acid sequence within SMC1, which includes phosphorylated Ser966 (NP_006297.2).
Recognizes the human nuclear protein SMC1 (structural maintenance of chromosomes 1), when phosphorylated at Ser966. SMC1 is a member of the evolutionary highly conserved SMC family of ATPases which play a vital role in the organization of chromosomes during mitosis. Eukaryotic SMC1 combines with SMC3, and with the two sister-chromatid cohesion proteins Scc1 and Scc3, to form the macromolecular cohesion complex, responsible for the linking of sister chromatids during metaphase. The SMC1-SMC3 heterodimer also combines with DNA polymerase E and ligase III to form the DNA recombination complex RC-1. Studies have shown that the phosphorylation of SMC1 on residues Ser966 and Ser957 by the protein kinase ATM, occurs following irradiation damage of DNA, and is required for the activation of the ATM/NBS1-dependent S-phase checkpoint response, with the presence of BRCA1 resulting in optimal phosphorylation.
Western Blot: LS-C56969 detects a band of approximately 160kD in HeLa whole cell lysates.


Tris buffered saline, 0.09% sodium azide, 0.1% BSA.
Short term: -20°C; Long term: -20°C.
For research use only.

About SMC1A / SMC1

Q14683 NM_006306 NP_006297.2

SMC1A Antibody, CDLS2 Antibody, DXS423E Antibody, KIAA0178 Antibody, SB1.8 Antibody, SMC protein 1A Antibody, SMC1 Antibody, SMC1L1 Antibody, SMC-1-alpha Antibody, SMC-1A Antibody, SMCB Antibody

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain.

Western blot

Western blot
Detection of human phospho-SMC1 (pSER966) in whole cell lysates of HeLa cells subjected to 10Gy gamma irradiation by Western blotting using Rabbit anti-Human phospho-SMC1(pSER966) (LS-C56969).

Requested From: 
Date Requested: 3/17/2018

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