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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMC1A / SMC1 Antibody (aa916‑927) LS‑C17946
SMC1 antibody LS-C17946 is an unconjugated rabbit polyclonal antibody to SMC1 (SMC1A) from human, mouse, rat and other species. Validated for WB.
Antibody
Catalog
Size
Price
LS-C17946-200
200 µg
$560

Popular SMC1A / SMC1 Products

Anti-SMC1A / SMC1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5432 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Antibody
Species: Human, Mouse, Xenopus
Applications: Immunofluorescence, Western blot, Immunoprecipitation
Anti-SMC1A / SMC1 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11277 concentration 5 ug/ml.
Species: Human, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Rabbit, Chicken, Xenopus laevis
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, Proximity Ligation Assay
Anti-SMC1A / SMC1 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11029 dilution 1:100.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence
IHC of paraffin-embedded human colon using SMC1 mouse monoclonal antibody with DAB staining.
Species: Human
Applications: IHC, Immunofluorescence, Western blot, Flow Cytometry, ELISA

Product Description

SMC1 antibody LS-C17946 is an unconjugated rabbit polyclonal antibody to SMC1 (SMC1A) from human, mouse, rat and other species. Validated for WB.

Specifications

Target
Human SMC1A / SMC1
Synonyms
SMC1A, CDLS2, DXS423E, KIAA0178, SB1.8, SMC protein 1A, SMC1, SMC1L1, SMC-1-alpha, SMC-1A, SMCB
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Chicken, Xenopus, Zebrafish (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot
  • (applications tested for the base form of this product only)
Immunogen
SMC1A / SMC1 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 916-927 of human SMC1 (C-ETKLEQKRSDRH) with a N-terminal cysteine. The immunizing sequence is identical in rat, bovine and Xenopus and has 11/12 identical amino acids in mouse. Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Pig, Chicken, Lizard, Xenopus, Stickleback, Pufferfish, Zebrafish (100%); Trichina worm (83%).
Epitope
aa916-927
Specificity
Recognizes SMC1, Mr 150kD. Additional proteins are detected at Mr 45kD and 140kD. All three proteins are competed by the immunizing peptide. Species cross-reactivity: Human. Predicted to cross-react with rat, bovine and Xenopus based on sequence homology.
Usage
Western Blot: 2 ug/ul.
Presentation
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About SMC1A / SMC1
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Q14683 NM_006306 NP_006297.2


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Requested From: United States
Date Requested: 10/16/2018

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