Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SMAD7 Antibody, CRCS3 Antibody, HSMAD7 Antibody, MAD homolog 7 Antibody, SMAD 7 Antibody, MADH7 Antibody, MADH8 Antibody, Mothers against DPP homolog 7 Antibody, Mothers against DPP homolog 8 Antibody, MAD homolog 8 Antibody, SMAD family member 7 Antibody
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
Smad7 Antibody IHC of formalin-fixed and paraffin-embedded lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Fluorescent confocal image of A431 cell stained with Smad7 Antibody. A431 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with Smad7 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). Smad7 immunoreactivity is localized to cytoplasm significantly.
Western blot of Smad7 Antibody in ZR-75-1 cell line lysates (35 ug/lane). Smad7 (arrow) was detected using the purified antibody.