Target
Human SLC44A1 / CD92
Synonyms
SLC44A1 | CD92 antigen | CTL1 | RP11-287A8.1 | CD92 | CDW92 | CDW92 antigen | CHTL1
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
FITC.
Also available conjugated with
RPE.
Immunogen
MV4-11 acute monocyte leukaemia cells
Specificity
Specific for the C-terminal variant of human CDw92 (isoform 3), also known as CTL1, a 70kD multi-pass membrane protein, expressed by monocytes, neutrophils, certain myeloid and T cell lines, and weakly by endothelial cells, fibroblasts and epithelial cells. CDw92 is a member of the choline transporter-like protein family, so called due to their involvement in the efficient supply/transport of the natural amine choline, a vital cell nutrient required for the synthesis of cell membrane phospholipid components and the neurotransmitter acetylcholine. Clone VIM-15b is reported to augment the LPS-induced production of IL-10 by monocyte-derived dendritic cells (Mo-DCs), and the reduced expression of CDw92 by Mo-DCs treated with ionomycin or calcium ionophore, can be reinduced in the presence of IL-10.