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ASCT1 functions primarily as a neutral amino acid exchanger. ASCT 1-mediated transport requires the presence of sodium ions but ASCT1 mediates only homo- and hetero exchange of amino acids and is insensitive to K+. The properties of ASCT1 suggest that it may function to equilibrate different pools of neutral amino acids and provide a mechanism to link amino acid concentration gradients. ASCT1 expression has been found at varying levels in every tissue examined.
Gene Name: | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
Family/Subfamily: | Transporter , Sodium:dicarboxylate symporter |
Synonyms: | SLC1A4, ASCT1, SATT, ASCT-1 |
Target Sequences: | NM_003038 NP_003029.2 P43007 |
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