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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SLC11A2 / DMT1 Antibody (C‑Terminus) LS‑C16687
DMT1 antibody LS-C16687 is an unconjugated rabbit polyclonal antibody to human DMT1 (SLC11A2). Validated for ELISA, IHC and WB. Cited in 1 publication.
Antibody
Catalog
Size
Price
LS-C16687-100
100 µg (1 mg/ml)
$755

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Product Description

DMT1 antibody LS-C16687 is an unconjugated rabbit polyclonal antibody to human DMT1 (SLC11A2). Validated for ELISA, IHC and WB. Cited in 1 publication.
About SLC11A2 / DMT1
Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate. P49281 NM_000617 NP_000608.1

SLC11A2 Antibody, Divalent metal transporter 1 Antibody, Divalent cation transporter 1 Antibody, DMT-1 Antibody, NRAMP 2 Antibody, NRAMP2 Antibody, Dct-1 Antibody, DCT1 Antibody, DMT1 Antibody


Specifications

Target
Human SLC11A2 / DMT1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC (5 - 20 µg/ml)
  • Western blot (1:1000 - 1:5000)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
SLC11A2 / DMT1 antibody was raised against a 17 AA Peptide sequence located at the predicted cytoplasmic loop near the C-terminus of human NRAMP2, with IRE (1). Coupled to KLH.
Epitope
C-Terminus
Specificity
Recognizes human Natural Resistance Associated Macrophage Protein (Nramp2). Species sequence homology: monkey 88%.
Usage
Suitable for use in ELISA, Immunohistochemistry and Western Blot. Immunohistochemistry: 5-20 ug/ml.
Presentation
Lyophilized from PBS, pH 7.4, 0.1% BSA
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.

Publications (1)

1
Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. Straud S, Zubovych I, De Brabander JK, Roth MG. PloS one. 2010 5:e11629. (WB; Human) [Full Text Article] [PubMed:20661293] [PMC:PMC2905441]

Customer Reviews (0)


Requested From: United States
Date Requested: 9/19/2018

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