LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us
SIRT6 / Sirtuin 6 Antibody (Internal, DY488) LS‑C141049
Sirtuin 6 antibody LS-C141049 is a DY488-conjugated rabbit polyclonal antibody to human Sirtuin 6 (SIRT6). Validated for WB.
Catalog
Size
Price
LS-C141049-100
100 µl
Unavailable

Popular SIRT6 / Sirtuin 6 Products

Anti-SIRT6 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B900 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, ELISA
Detection of SIRT6 in MEF lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Mouse
Applications: IHC, IHC - Paraffin, Western blot
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot
Anti-SIRT6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5588 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Rat, Bovine, Dog
Applications: IHC, IHC - Paraffin, Western blot
Anti-SIRT6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5589 concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Bat, Dog, Hamster, Pig
Applications: IHC, IHC - Paraffin, Western blot

Product Description

Sirtuin 6 antibody LS-C141049 is a DY488-conjugated rabbit polyclonal antibody to human Sirtuin 6 (SIRT6). Validated for WB.
About SIRT6 / Sirtuin 6
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Q8N6T7 NM_016539 NP_057623.2

SIRT6 Antibody, SIR2-like protein 6 Antibody, Sirtuin type 6 Antibody, SIR2L6 Antibody, Sir2-related protein type 6 Antibody, Sirtuin 6 Antibody


Specifications

Target
Human SIRT6 / Sirtuin 6
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
DyLight 488. Also available Unconjugated or conjugated with Biotin, DY650, DY550.
Purification
Affinity purified
Modifications
Unmodified
Applications
  • Western blot (2 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
A synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350). [Swiss-Prot Q8N6T7] Percent identity by BLAST analysis: Mouse (78%); Rat (71%).
Epitope
Internal
Specificity
SIRT6.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
50 mM sodium borate
Storage
Store at 4°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (0)


Customer Reviews (0)


Images


Western blot

Detection of SIRT6 in HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of SIRT6 in HeLa whole cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of SIRT6 in HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of SIRT6 in HeLa whole cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of SIRT6 in HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of SIRT6 in HeLa whole cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of SIRT6 in HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of SIRT6 in HeLa whole cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/23/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number