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Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
Gene Name: | suppressor of IKBKE 1 |
Synonyms: | SIKE1, RP5-1000E10.4, SIKE, Suppressor of IKK epsilon, Suppressor of IKBKE 1, Suppressor of IKK-epsilon |
Target Sequences: | NM_025073 NP_079349.2 Q9BRV8 |
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