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Anti-SIGLEC7 / CD328 Antibody (clone 5-386) LS-C58033

Note: This antibody replaces LS-C58112

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $275
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular SIGLEC7 / CD328 Antibodies

Anti-SIGLEC7 / CD328 Antibody (clone 5-386, FITC) LS-C58113
Mouse Monoclonal [clone 5-386] (IgG1) to Human SIGLEC7 / CD328
Human
IHC - Frozen, Flow Cytometry
FITC Conjugated
Anti-SIGLEC7 / CD328 Antibody (PE) LS-C132108
Mouse Monoclonal (IgG1) to Human SIGLEC7 / CD328
Human
Flow Cytometry
PE Conjugated
Anti-SIGLEC7 / CD328 Antibody (aa1-30) IHC-plus™ LS-B6906
Rabbit Polyclonal to Human SIGLEC7 / CD328
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 5-386] (IgG1) to Human SIGLEC7 / CD328
Human
IHC - Frozen, Flow Cytometry (applications tested for the base form of this product only)
Unconjugated

Details

Human SIGLEC7 / CD328
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [5-386]
Unconjugated. Also available conjugated with RPE, FITC.
Affinity purified
Unmodified

Applications

  • IHC - Frozen (1:100)
  • Flow Cytometry (1:100 - 1:200)
  • (applications tested for the base form of this product only)

Specificity and Use

SIGLEC7 / CD328 antibody was raised against monocyte-derived dendritic cells.
Specific for human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About SIGLEC7 / CD328

Q9Y286 NM_014385 NP_055200.1

SIGLEC7 Antibody, AIRM-1 Antibody, AIRM1 Antibody, CD328 antigen Antibody, CDw328 Antibody, CD328 Antibody, D-siglec Antibody, QA79 Antibody, SIGLEC-7 Antibody, QA79 membrane protein Antibody

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Requested From: United States
Date Requested: 12/3/2016

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