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Anti-SIGLEC10 Antibody (clone 5G6) LS-C187565

Catalog Size Price
LS-C187565-100 100 µg (1 mg/ml) Unavailable

Related Products

24 SIGLEC10 Antibodies

Most Popular SIGLEC10 Antibodies

Anti-SIGLEC10 Antibody (clone 5G6) LS-C187565
Mouse Monoclonal [clone 5G6] (IgG1) to Human SIGLEC10
Human
Flow Cytometry
Unconjugated
Flow Cytometry Image
Anti-SIGLEC10 Antibody (C-Terminus, AP) LS-C240769
Rabbit Polyclonal (IgG) to Human SIGLEC10
Human
Western blot, ELISA
AP Conjugated
Anti-SIGLEC10 Antibody (aa666-695) LS-C325111
Rabbit Polyclonal (IgG) to Human SIGLEC10
Human
Western blot, ELISA
Unconjugated
Anti-SIGLEC10 Antibody (C-Terminus) LS-C330127
Rabbit Polyclonal (IgG) to Human SIGLEC10
Human
Western blot, ELISA
Unconjugated
Anti-SIGLEC10 Antibody LS-C406781
Rabbit Polyclonal (IgG) to Human SIGLEC10
Human
IHC, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed
Mouse Monoclonal [clone 5G6] (IgG1) to Human SIGLEC10
Human
Flow Cytometry (applications tested for the base form of this product only)
Unconjugated

Details

Human SIGLEC10
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [5G6]
Unconjugated. Also available conjugated with FITC.
Protein G purified
Unmodified

Applications

  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

SIGLEC10 antibody was raised against recombinant human Siglec-10, fused with the Fc region of human IgG.
Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About SIGLEC10

Q96LC7 Q96LC7

SIGLEC10 Antibody, SIGLEC-10 Antibody, Siglec-like gene 2 Antibody, Siglec-like protein 2 Antibody, PRO940 Antibody, SLG2 Antibody

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Flow Cytometry

Flow Cytometry
Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 12/11/2017

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