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SIGLEC10 Antibody (clone 5G6) LS‑C187565 Best Seller
SIGLEC10 antibody LS-C187565 is an unconjugated mouse monoclonal antibody to human SIGLEC10. Validated for Flow.
Catalog
Size
Price
LS-C187565-100
100 µg (1 mg/ml)
Unavailable

Popular SIGLEC10 Products

Western blot of recombinant SIGLEC10 / SIGLEC-10.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Product Description

SIGLEC10 antibody LS-C187565 is an unconjugated mouse monoclonal antibody to human SIGLEC10. Validated for Flow.
About SIGLEC10
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Q96LC7 Q96LC7

SIGLEC10 Antibody, SIGLEC-10 Antibody, Siglec-like gene 2 Antibody, Siglec-like protein 2 Antibody, PRO940 Antibody, SLG2 Antibody


Specifications

Target
Human SIGLEC10
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [5G6]
Conjugations
Unconjugated. Also available conjugated with FITC.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Immunogen
SIGLEC10 antibody was raised against recombinant human Siglec-10, fused with the Fc region of human IgG.
Specificity
Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.
Presentation
PBS, 0.09% sodium azide
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Flow Cytometry

Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/18/2018

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