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Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Gene Name: | SH3 and multiple ankyrin repeat domains 1 |
Synonyms: | SHANK1, SPANK-1, SSTR-interacting protein, Synamon, SSTRIP |
Target Sequences: | NM_016148 NP_057232.2 Q9Y566 |
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