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Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Gene Name: | SH3 and PX domains 2B |
Synonyms: | SH3PXD2B, Adapter protein HOFI, Adaptor protein HOFI, HOFI, FTHS, KIAA1295, TKS4, FAD49, SH3 and PX domains 2B, TSK4 |
Target Sequences: | A1X283 A1X283 |
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