Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2D8] (IgG1) to Human SH2B3 / LNK
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Goat Polyclonal to Human SH2B3 / LNK
Western blot, ELISA
Human SH2B3 / LNK
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Western blot (1:64000) & (0.3 - 1 µg/ml)
IHC - Paraffin
Specificity and Use
SH2B3 / LNK antibody was raised against synthetic peptide NGPALQPSSPC from the N-terminus of human SH2B3 (NP_005466.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (90%), Monkey (90%), Marmoset (90%), Panda (80%), Dog (80%), Rabbit (80%), Pig (80%).
LS-E25756 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C55071. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
SH2B3 Antibody, LNK Antibody, IDDM20 Antibody, Lymphocyte adapter protein Antibody, SH2B adapter protein 3 Antibody, SH2B adaptor protein 3 Antibody
SH2B3 / LNK is a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.