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Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Gene Name: | splicing factor 3b, subunit 4, 49kDa |
Synonyms: | SF3B4, AFD1, Hsh49, SAP 49, Spliceosomal protein, SF3b50, SAP49, SF3b49, Splicing factor 3B subunit 4 |
Target Sequences: | NM_005850 NP_005841.1 Q15427 |
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