Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ICC, Immunofluorescence, Western blot, Immunoprecipitation
Rabbit Polyclonal to Human SETX / Senataxin
Western blot, Immunoprecipitation, ELISA
Human SETX / Senataxin
Human (tested or 100% immunogen sequence identity)
Western blot (1:1000 - 1:2000)
Specificity and Use
SETX / Senataxin antibody was raised against antibody was affinity purified using an epitope specific to Senataxin immobilized on solid support. The epitope recognized by A301-105A maps to a region between residue 2627 and 2677 of human senataxin using the numbering given in entry NP_055861.2.
Recognizes human RBM25.
Suitable for use in ELISA, Western Blot and Immunoprecipitation. Western Blot: 1:1000-1:2000.
Tris-citrate/phosphate buffer, pH 7 to 8
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
SETX / Senataxin is a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).