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Anti-SERPINB9 / PI9 Antibody LS-C44956


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $290
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular SERPINB9 / PI9 Antibodies

Anti-SERPINB9 / PI9 Antibody LS-C17406
Mouse Monoclonal (IgG1) to Human SERPINB9 / PI9
IHC - Paraffin, Western blot, Flow Cytometry
Anti-SERPINB9 / PI9 Antibody (aa66-328) LS-C178501
Rabbit Polyclonal to Human SERPINB9 / PI9
Western blot, ELISA
Western blot Image
Anti-SERPINB9 / PI9 Antibody (clone 7D8) LS-C179710
Mouse Monoclonal [clone 7D8] (IgG1) to Human SERPINB9 / PI9
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG1) to Human SERPINB9 / PI9
IHC - Paraffin, Western blot, Flow Cytometry


Human SERPINB9 / PI9
Human (tested or 100% immunogen sequence identity)
Mouse, Pig
IgG1 Monoclonal
Protein G purified


  • IHC - Paraffin (1:50)
  • Western blot
  • Flow Cytometry (1:10 - 1:100)

Specificity and Use

SERPINB9 / PI9 antibody was raised against recombinant PI-9 produced in P. pastoris.
Specific for human PI-9 (proteinase inhibitor 9), also known as SerpinB9, a 42kD intracellular nucleocytoplasmic serpin expressed in cytotoxic lymphocytes (CTLs), natural killer (NK) cells, monocyte-derived dendritic cells (DCs), and to a lesser extent in B cells and myeloid cells. Granzyme B (grB) is a serine protease highly expressed by CTLs and NK cells, which is endocytosed by virus-infected and malignant target cells. The subsequent release of grB from the endocytic vesicles into the cytoplasm of the target cells, triggers grB-mediated apoptosis, through cleavage of various cytoplasmic or nuclear proteins. PI-9, up-regulated in response to grB production and degranulation, has been identified as a potent inhibitor of Granzyme B-mediated apoptosis, providing a vital self-protection mechanism against the premature apoptosis of CTLs and NK cells by grB, which may escape into the cytoplasm of the effector cells themselves. Clone Detects a band of approximately 42kD under reducing conditions. Clone 7D8 is suitable for use in indirect Immunofluorescence.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100ul. Membrane permeabilization is required for this application. Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Histology Positive Control Tissue: Tonsil.


PBS, 0.05% sodium azide.
For research use only.

About SERPINB9 / PI9

P50453 NM_004155 NP_004146.1

SERPINB9 Antibody, CAP-3 Antibody, CAP3 Antibody, Cytoplasmic antiproteinase 3 Antibody, Peptidase inhibitor 9 Antibody, Serpin B9 Antibody, PI-9 Antibody, PI9 Antibody

SERPINB9 / PI9 is a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6.

Requested From: United States
Date Requested: 10/28/2016

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