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Anti-SELE / CD62E / E-selectin Antibody (clone 4D10, FITC) LS-C96263

Ordering

Wt. Vol. Conc. Price
500 µg - - $465
Inquire for larger quantities

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Most Popular SELE / CD62E / E-selectin Antibodies

Anti-SELE / CD62E / E-selectin Antibody LS-C13905
Mouse Monoclonal (IgG2a) to Human SELE / CD62E / E-selectin
Human
Immunofluorescence, Flow Cytometry
Unconjugated
Anti-SELE / CD62E / E-selectin Antibody (aa33-50) LS-C312860
Rabbit Polyclonal (IgG) to Human SELE / CD62E / E-selectin
Human, Monkey, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone 4D10]
Human
FITC Conjugated

Details

SELE / CD62E / E-selectin
Rat
Human (tested or 100% immunogen sequence identity)
Monoclonal [4D10]
Fluorescein
Affinity purified
Unmodified

Specificity and Use

SELE / CD62E / E-selectin antibody was raised against lPS-stimulated human endothelial cells
The antigen is CD62E, the epitope has not been characterized. Antigen distribution: Isolated cells: Positive on LPS, TNFa, IL-1, or TPA stimulated endothelial cells (HUVECs) in tissue culture. No cross reactivity with other cell types known. Tissue sections: Strongly positive on human endothelial cells in acutely inflamed tissues such as atopic dermatitis or contact dermatitis 24h after sensitization; in the healthy spleen and lymph node. Few single cells express the 4D10 antigen. The antigen is generally absent in chronically inflamed tissues. Biochemistry: The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders. Specificity: Human: CD62E. Other: Not tested.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS pH 7.2, 10mg/ml BSA, 0.1% sodium azide
Store at 4°C.
For research use only.

About SELE / CD62E / E-selectin

P16581 NM_000450 NP_000441.2

SELE Antibody, CD62E Antibody, ELAM Antibody, ESEL Antibody, E-selectin Antibody, LECAM2 Antibody, CD62E antigen Antibody, ELAM-1 Antibody, ELAM1 Antibody, Selectin E Antibody

SELE / CD62E / E-selectin is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules.

Requested From: United States
Date Requested: 2/23/2017

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