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Anti-Securin / PTTG1 Antibody (Azide-free) LS-C74225


Wt. Vol. Conc. Price
- 100 µl - Unavailable

Most Popular Securin / PTTG1 Antibodies

Anti-Securin / PTTG1 Antibody (N-Terminus) LS-C9840
Rabbit Polyclonal (IgG) to Human Securin / PTTG1
IHC - Paraffin, Western blot, ELISA
Anti-Securin / PTTG1 Antibody (clone DCS-280, Azide-free) LS-C87800
Mouse Monoclonal [clone DCS-280] (IgG2a,k) to Human Securin / PTTG1
IHC - Paraffin
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (aa148-160) IHC-plus™ LS-B5119
Goat Polyclonal to Human Securin / PTTG1
Human, Monkey, Mouse
IHC - Paraffin
Immunohistochemistry Image
Anti-Securin / PTTG1 Antibody (Internal) LS-C153548
Rabbit Polyclonal to Human Securin / PTTG1
Human, Mouse
IHC, Western blot, ELISA
Anti-Securin / PTTG1 Antibody (Leu149) LS-C176719
Rabbit Polyclonal to Human Securin / PTTG1
IHC - Paraffin, Immunofluorescence, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2a) to Human Securin / PTTG1
IHC - Paraffin (applications tested for the base form of this product only)
Unconjugated, Azide-free


Human Securin / PTTG1
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, MaxLight 405, MaxLight 490, MaxLight 550, MaxLight 650, MaxLight 750, PE.
Protein A purified


  • IHC - Paraffin
  • (applications tested for the base form of this product only)

Specificity and Use

Securin / PTTG1 antibody was raised against human recombinant full length Pds1 protein.
Recognizes Pds1. Species cross-reactivity: human.
Western Blot (Not verified), Immunohistochemistry (formalin/paraffin) (Ab 1-2 ug/ml for 30 min at RT). Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive control: HeLa cells. Tonsil. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.


10 mM PBS, pH 7.4.
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Antibody, EAP1 Antibody, Esp1-associated protein Antibody, HPTTG Antibody, ESP1-associated protein 1 Antibody, Pituitary tumor-transforming 1 Antibody, TUTR1 Antibody, PTTG Antibody, Securin Antibody, Tumor-transforming protein 1 Antibody

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: 
Date Requested: 4/23/2017

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