Human Secretory Component

Sheep

Human (tested or 100% immunogen sequence identity)

Polyclonal

Unconjugated

Immunoaffinity absorbed

Unmodified

Human secretory IgA.

Human IgA Secretory Component (IgAs). The reactivity of the antiserum is restricted to the Fc part of the IgA molecule and to surface and hidden determinants of the secretory component as tested in immunoelectrophoresis and radial immunodiffusion. In immunoelectrophoresis using various antiserum concentrations against normal human milk two precipitin lines may be obtained, one representing IgA and the other the free secretory component. Against normal human serum only IgA is precipitated. No precipitation reaction is obtained with purified IgG, IgM, and IgG/Fab fragments. Cross-reactivity The antiserum does not cross-react with any other component of the human Ig system. Inter- species cross-reactivity is a normal feature of antibodies to immunoglobulins, since Ig of different species frequently share antigenic determinants. Cross-reactivity of this antiserum has not been tested in detail.

• Immunodiffusion

This product is intended for use in precipitating techniques as immunoelectrophoresis and radial immunodiffusion to identify the presence of IgA in human serum, milk or other body fluids or to determine its concentration. To prepare an immunoadsorbent for the purification of human IgA from serum or exocrine secretions. Antisera to IgA do not discriminate between serum IgA (monomeric and dimeric) and higher molecular forms as secretory IgA. This antiserum is not intended for use in non-precipitating antibody-binding or other highly sensitive assays. This does not exclude such use if proper controls are include.

Lyophilized antiserum

Use 1 ml of sterile Distilled water.

Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.