Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1E5] (IgG2b,k) to Human SDF1 / CXCL12
Rabbit Polyclonal to Mouse SDF1 / CXCL12
IHC, Western blot, Immunoprecipitation
Mouse SDF1 / CXCL12
Mouse, Rat (tested or 100% immunogen sequence identity)
Protein A purified
IHC - Paraffin
Specificity and Use
SDF1 / CXCL12 antibody was raised against e. coli-expressed mouse SDF-1 beta.
The antibody can be used for Western blot analysis (1 ug/ml), immunoprecipitation (4-8 ug/ml), and immunohistochemistry (10-20 ug/ml). Cross-reactivity to SDF-1 beta of other species has not been determined
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity.