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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SCN1A / Nav1.1 Antibody (N‑Terminus) IHC‑plus™ LS‑A9589 Best Seller
Nav1.1 antibody LS-A9589 is an unconjugated rabbit polyclonal antibody to Nav1.1 (SCN1A) from human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A9589-50
50 µg (1 mg/ml)
Unavailable
In Stock for Immediate Shipment

Popular SCN1A / Nav1.1 Products

Western blot of extracts from mouse brain tissue, using Na+ CP type I alpha antibody.
Species: Human, Mouse, Rat
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Western blot of Na+ CP-pan antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot, ELISA
Western blot analysis of Scn1a expression in rat brain extract (lane 1), mouse brain extract (lane 2) and U87 whole cell lysates (lane 4). Scn1a at 250 kD was detected using rabbit anti- Scn1a Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Species: Human, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Sheep
Applications: Western blot

Product Description

Nav1.1 antibody LS-A9589 is an unconjugated rabbit polyclonal antibody to Nav1.1 (SCN1A) from human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About SCN1A / Nav1.1
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. P35498 NM_006920 NP_008851.3

SCN1A Antibody, Brain sodium channel type I Antibody, FEB3A Antibody, FHM3 Antibody, GEFSP2 Antibody, EIEE6 Antibody, HBSC I Antibody, HBSCI Antibody, GEFS+2 Antibody, NAC1 Antibody, Nav1.1 Antibody, SCN1 Antibody, SMEI Antibody, FEB3 Antibody, Febrile convulsions 3 Antibody, RBI Antibody


Specifications

Target
Human SCN1A / Nav1.1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus (tested or 100% immunogen sequence identity)
Predicted
Bovine, Zebrafish (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
SCN1A / Nav1.1 antibody was raised against synthetic 16 amino acid peptide from N-terminus of human SCN1A / Nav1.1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Horse, Rabbit, Pig, Turkey, Chicken, Platypus, Xenopus, Pufferfish (100%); Bovine, Opossum, Stickleback, Zebrafish (94%).
Blocking Peptide
LS-E29699 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A9589. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human SCN1A / Nav1.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SCN2A (100%), SCN3A (94%).
Presentation
PBS, less than 0.1% sodium azide.
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Immunohistochemistry

Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SCN1A / Nav1.1 antibody LS-A9589 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.


Requested From: 
Date Requested: 6/24/2018

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