Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 10B10G] (IgG1) to Salmonella O Antigens
Immunofluorescence, Western blot, ELISA
Salmonella O Antigens
Salmonella (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [10B10G]
Specificity and Use
Heat inactivated cells of Salmonella paratyphi A.
Recognizes the O antigen of Salmonella enterica, serovar paratyphi A (also known as S. paratyphi). The O antigen is a polysaccharide that extends from the core oligosaccharide, which itself is attached to lipid A. These three components together form the lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria. The LPS is an endotoxin and induces a strong immune response from the host. Its mutation or removal results in the death of the bacterial cell and as such is a prime target for antimicrobial drugs. The O antigen is the outermost component of the LPS and functions as a receptor for bacteriophages. It is also important in the immune response of the host. Considerable diversity is seen within Salmonella O antigens. Salmonella enterica, serovar paratyphi A belongs to serogroup A of Salmonella and causes paratyphoid fever, which is similar to typhoid fever but more benign. Specific for the 0-2 antigenic determinant of Salmonella serogroup A and does not cross-react with the LPS of serogroups B, D or E of Salmonella spp.