Human S100A8 / MRP8

Mouse

Human (tested or 100% immunogen sequence identity)

Monoclonal

S13-67

Unconjugated

Affinity purified

Unmodified

Cultured human monocytes

The antigen is MRP8, the epitope is suspected in the N- or C- terminal domain. Antigen distribution: Isolated cells: The antigen is found in granulocytes and monocytes. It is absent from other blood cells. In cultured monocytes, maximum MRP8 levels occur after 3 - 4 days. Tissue sections: MRP8 is found in a distinct subpopulation of inflammatory perivascular infiltrates of the myelo-monocytic lineage. Macrophages increasingly synthesise MRP8 during the late stages of inflammation. A low MRP8 (and high MRP14) expression by macrophages was also reported in granulomatous diseases such as tuberculosis and sarcoidis. In non-granulomatous chronic inflammatory diseases such as chronic rheumatoid arthritis, MRP8 and MRP14 positive cells consist of different subpopulations. During early inflammation endothelial cells are also positive with MRP8 / MRP14. Specificity: Human: granulocytes, stimulated monocytes and macrophages. Other: rat; cow; pig (TNF-alpha/IL-1 alpha induced inflammation of the skin).

• IHC
• IHC - Paraffin
• ELISA

Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal

Reconstitute with 0.5ml distilled H2O.

Store at 4°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05109 NCBI: NM_002964 NP_002955.2