Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified
Applications
Western blot (1 - 10 µg/ml)
ELISA (1:10000 - 1:100000)
Specificity and Use
RTN4 / Nogo antibody was raised against an 11aa peptide within the N-terminal, extracellular domain of human Nogo-C.(KLH coupled).
N-Terminus
Recognizes Neurite Outgrowth Inhibitor Protein C (NogoC). Species sequence Homology: human Nogo-C/foocen-S/RTN 4:100%; mouse Nogo-C/foocen-S/RTN 4:81%. Most of this region is unique to Nogo-C and not conserved in Nogo-A/B isoforms.
Suitable for use in ELISA and Western Blot. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide/well. Western Blot: 1-10 ug/ml using ECL.
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity).