Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Bovine (tested or 100% immunogen sequence identity)
Protein A purified
Western blot (1:5000 - 1:10000)
Specificity and Use
RPE65 antibody was raised against bovine RPE microsomal membrane proteins. Cellular Localization: Cytoplasmic.
Recognizes RPE65. Tested in bovine, porcine, human and murine.
Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Western Blot: 1:5000-1:10000, recognizes a band at 65kD, representing bovine RPE65 protein. Immunohistochemistry: 1:250. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT.