Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone G28-8] (IgG1) to Human RP105 / CD180
Mouse Monoclonal (IgG1) to Human RP105 / CD180
IHC, IHC - Paraffin, IHC - Frozen, Flow Cytometry
Human RP105 / CD180
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen (1:50)
Flow Cytometry (1:50)
Specificity and Use
RP105 / CD180 antibody was raised against human CD180.
Recognizes human CD180.
Suitable for use in Flow Cytometry and Immunohistochemistry. Flow Cytometry: 1:50. Immunohistochemistry (frozen): 1:50. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 1% BSA, 0.02% sodium azide
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. FITC conjugates are sensitive to light.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.