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RNF14 / ARA54 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Gene Name: | ring finger protein 14 |
Synonyms: | RNF14, HRIHFB2038, HFB30, Triad2 protein, ARA54, Ring finger protein 14, TRIAD2 |
Target Sequences: | NM_004290 NP_004281.1 Q9UBS8 |
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