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Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.
Gene Name: | RAP1 interacting factor homolog (yeast) |
Synonyms: | RIF1 |
Target Sequences: | U79263 NP_060621.3 Q5UIP0 |
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