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RGS6 is a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.
Gene Name: | regulator of G-protein signaling 6 |
Family/Subfamily: | Regulator of G-protein signalling , not assigned-Regulator of G-protein signalling |
Synonyms: | RGS6, GAP, GTPase activating protein, S914, H_DJ1108A12.1, WUGSC:H_DJ0283M22.1, WUGSC:H_DJ1108A12.1 |
Target Sequences: | NM_004296 NP_004287.3 P49758 |
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