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Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Gene Name: | regulator of G-protein signaling 19 |
Family/Subfamily: | Regulator of G-protein signalling , not assigned-Regulator of G-protein signalling |
Synonyms: | RGS19, GNAI3IP, G alpha interacting protein, G-alpha-interacting protein, RGSGAIP, GAIP |
Target Sequences: | NM_005873 NP_005864.1 P49795 |
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