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Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Gene Name: | Reversion-inducing-cysteine-rich Protein With Kazal Motifs |
Synonyms: | RECK, HRECK, ST15 |
Target Sequences: | NM_021111 NP_066934.1 O95980 |
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