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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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RDH12 / LCA3 Antibody (aa215‑264) LS‑C111452
LCA3 antibody LS-C111452 is an unconjugated rabbit polyclonal antibody to LCA3 (RDH12) from human, bovine, guinea pig and other species. Validated for WB.
Catalog
Size
Price
LS-C111452-50
50 µg
Unavailable

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Product Description

LCA3 antibody LS-C111452 is an unconjugated rabbit polyclonal antibody to LCA3 (RDH12) from human, bovine, guinea pig and other species. Validated for WB.
About RDH12 / LCA3
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. Q96NR8 Q96NR8

RDH12 Antibody, LCA13 Antibody, LCA3 Antibody, Retinol dehydrogenase 12 Antibody, SDR7C2 Antibody


Specifications

Target
Human RDH12 / LCA3
Host
Rabbit
Reactivity
Human, Bovine, Guinea pig, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Dog, Zebrafish (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
RDH12 / LCA3 antibody was raised against synthetic peptide located between aa215-264 of human RDH12 (Q96NR8, NP_689656). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey (100%); Galago, Marmoset, Dog, Bat, Platypus, Zebrafish (92%); Orangutan, Horse, Pig (85%); Bovine, Rabbit, Opossum, Zebra finch, Chicken, Salmon (84%); Sea squirt (83%); Rat (76%).
Blocking Peptide
LS-E19099 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C111452. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa215-264
Specificity
Human RDH12
Usage
Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
Presentation
Lyophilized from PBS with 2% sucrose
Reconstitution
Distilled water
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RDH12 antibody LS-C111452 Western blot of Fetal Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/21/2018

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