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Anti-RBL2 / RB2 p130 Antibody (C-Terminus) IHC-plus™ LS-B414

Note: This antibody replaces LS-C18885, LS-C17613

Ordering

Wt. Vol. Conc. Price
- 50 µl 85 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular RBL2 / RB2 p130 Antibodies

Anti-RBL2 / RB2 p130 Antibody (C-Terminus) IHC-plus™ LS-B414
Rabbit Polyclonal to Human RBL2 / RB2 p130
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-RBL2 / RB2 p130 Antibody (clone 130P215) IHC-plus™ LS-B8633
Mouse Monoclonal [clone 130P215] (IgG1) to Human RBL2 / RB2 p130
Human, Rat
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human RBL2 / RB2 p130
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human RBL2 / RB2 p130
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • IHC - Paraffin (1:500)
  • Western blot (1:500 - 1:2000)
  • Immunoprecipitation (1:100)
  • ELISA (1:5000 - 1:20000)

Specificity and Use

C-Terminus
Rb2 (p130) peptide corresponding to a region near the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Immunohistochemistry: LS-B414 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B414 was determined to be 1:500.

Packaging

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About RBL2 / RB2 p130

Q08999 NM_005611 NP_005602.3

RBL2 Antibody, p130 Antibody, Retinoblastoma-like 2 (p130) Antibody, RBR-2 Antibody, Rb2 Antibody, Retinoblastoma-like protein 2 Antibody

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.

Immunohistochemistry

Immunohistochemistry
Anti-RBL2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B414 dilution 1:500.
 

Requested From: United States
Date Requested: 12/9/2016

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