Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Paraformaldehyde fixed frozen section of adult rat cortex stained with RBFOX3 / NEUN antibody in red and counterstained for DNA in blue. Note that RBFOX3 / NEUN antibody stains neuronal nuclei and distal perikarya, exactly like the original NeuN monoclonal antibody and like NeuN/Fox3 monoclonal IB7. These antibodies do not bind to the nuclei of perikarya of non-neuronal cells, so that they can be used to identify neurons.
Western blot of rat brain homogenates stained with RBFOX3 / NEUN antibody. Antibody binds closely spaced 48 and 46kDa bands.