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In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Gene Name: | retinoblastoma binding protein 5 |
Synonyms: | RBBP5, RBBP-5, SWD1, RBQ3 |
Target Sequences: | NM_005057 NP_005048.2 Q15291 |
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