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Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Gene Name: | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 |
Synonyms: | RASSF7, C11orf13, HRAS1, HRAS1-related cluster-1, HRC1 |
Target Sequences: | NM_003475 NP_003466.1 Q02833 |
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